Correlation of vitamin K-dependent clotting factors with cholesterol and triglycerides in healthy young adults.

نویسندگان

  • C J Hoffman
  • W E Lawson
  • R H Miller
  • M B Hultin
چکیده

The plasma level of factor VII activity was a risk factor for the development of ischemic heart disease (IHD) in a prospective epidemiological study of hemostatic factors. We have previously reported significant correlations between factor VII clotting activity or antigen and lipid fractions in a group of 132 young men (< 30 years old) at low risk for IHD and concluded that control of the plasma factor VII level may be linked to lipid metabolism in normal male physiology. Because factor VII is one of four vitamin K-dependent procoagulant proteins, we hypothesized that plasma levels of all these proteins would be similarly controlled in normal physiology. In an extension of this study, we have measured two additional vitamin K-dependent clotting factors (prothrombin [factor II] and factor X activity), as well as factor VII activity and antigen and fasting serum lipid fractions in healthy young men and women (< 30 years old) at low risk for IHD. In the women, we found significant positive correlations of factor VII antigen with total or HDL cholesterol and of prothrombin or factor X with total or LDL cholesterol. In the men, factor VII activity or antigen correlated with total cholesterol, triglycerides, HDL cholesterol, or LDL cholesterol; prothrombin or factor X correlated with total cholesterol, triglycerides, or LDL cholesterol. In contrast, we found no significant correlations of fibrinogen with any of the lipid fractions in our groups of men or women. Our data support the hypothesis that control of the levels of the vitamin K-dependent procoagulant proteins is linked to lipid metabolism in the normal physiology of both men and women.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

A case report of temporary and acquired vitamin K-dependent clotting factor deficiency without any response to administrated vitamin K

Abstract Background and Objectives Vitamin K-dependent clotting factor deficiency (VKCFD) is usually an acquired problem due to liver disease, malabsorption, and overdose of warfarin.  In the present paper the significance and role of vitamin K-dependent coagulation factors in menorrhagia were evaluated.   Case We present a rare case of 43 year woman with acquired vitamin K deficiency and se...

متن کامل

Serum Vitamin D status and its relations to body fatness and fitness and risk factors in young adults

The study examined the relations of serum vitamin D levels to body fatness, cardiorespiratory fitness (CRF), and metabolic risk factors in young adults in Korea. A total of 593 young men completed a health examination, body fatness, maximal treadmill exercise test, and assessment of metabolic risk factors. Participants were classified by serum vitamin D levels as deficient (< 20 ng/mL), insuffi...

متن کامل

ارزیابی عوامل مؤثر در پراکسیداسیون لیپیدی بیماران همودیالیزی و پیوندی

Evaluation the Affecting Factors in Lipid Peroxidation of Hemodialysis and Renal Transplanted Patients GR. Moshtaghi Kashanian PhD , N. Rashtchi PhD , H. Ardakani MD , A. Ghorbani Haghjoo PhD2 Received: 23/07/05 Sent for Revision: 25/09/06 Received Revised Manuscript: 21/01/07 Accepted: 26/02/07 Background and Objective: Atherosclerosis is the most important cause of death in hemodial...

متن کامل

Vitamin A intake is inversely related with adiposity in healthy young adults.

Dietary intake, either through specific nutrients or representative food groups, can influence obesity-related oxidative stress markers. This study evaluated the potential associations between vitamin A intake and several anthropometrical, biochemical and dietary features in healthy young adults, emphasizing the putative relationships between total antioxidant consumption and vitamin A intake. ...

متن کامل

Serum 25(OH)D is inversely associated with metabolic syndrome risk profile among urban middle-aged Chinese population

BACKGROUND Vitamin D deficiency is associated with a variety of chronic metabolic diseases. Limited evidence regarding vitamin D deficiency exists within the Chinese population. The present study aims to examine the association between serum vitamin D concentrations and cardiometabolic risk factors in the young and middle-aged, urban Chinese population METHODS The cross-sectional relationship...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Arteriosclerosis and thrombosis : a journal of vascular biology

دوره 14 11  شماره 

صفحات  -

تاریخ انتشار 1994